Vol.1 | Issue 1

Xanthine Oxidoreductase Mediates Nitrite-Induced Platelet Inhibition

Tipparat Parakaw, Rayomand Khambata, Amrita Ahluwalia * / 2020-12-31

Xanthine oxidoreductase (XOR) is a potential missing link in platelet hyperactivity and cardiovascular diseases. Bioconversion of NO2- to NO by XOR modulates platelet reactivity as we observed rises in plasma NO2- levels after Xdh allele deletion in mice. This higher plasma NO2- in Xdh heterozygous…